![]() Local skin necrosis and interstitial nephritis have also been associated with these creams 5. Another route of application is with sports creams used in massage therapy for muscle pain. Psoriasis is the main entity still treated with topical salicylates, and there are numerous case reports documenting toxicity 4. A review of the literature of topical salicylates reported 17 documented cases of toxicity associated with underlying illnesses, days to diagnosis, and serum salicylate 5. One case series reported 13 deaths, 10 of them in children, substantiating the severe potential for toxicity associated with this route 4. Prior to antibiotics, topical salicylates were widely used to treat scabies and impetigo, and toxicity associated with dermal absorption was common. Insidious cases of salicylate intoxication may also occur, caused by either ingestion or topical absorption, most often in elderly patients with renal failure. ![]() Salicylate is also available for topical application, in creams or lotions. Salicylate is available for ingestion as tablets, capsules, and liquids. The chemical is odorless and is soluble in water. Low-dose aspirin helps to prevent thrombosis.Īcetylsalicylic acid (aspirin) is colorless or white in crystalline, powder, or granular form. Aspirin is also used to treat acute coronary syndrome. Aspirin is most commonly used analgesic, antipyretic, anti-inflammatory and antiplatelet medication for the treatment of soft tissue and joint inflammation and vasculitides such as acute rheumatic fever and Kawasaki disease. Salicylates are used as analgesic agents for the treatment of mild to moderate pain. Salicylates and aspirin (acetylsalicylic acid) are ubiquitous agents found in hundreds of over-the-counter (OTC) medications and in numerous prescription drugs, making salicylate toxicity an important cause of morbidity and mortality 3. ![]() ![]() Complications increased when the diagnosis was not made upon initial evaluation 2. Overall the mortality was less than 0.01% however, this increased to 15% for patients with severe toxicity. In 2011 there were 30,000 cases of salicylate toxicity in the United States with 39 deaths 1. Salicylate toxicity is a medical emergency. Salicylate poisoning prognosis Salicylate poisoning
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